The PCOS supplement for women for life

Insulin Resistance & PCOS

Insulin resistance (IR) plays an important role in 65-80% of women with PCOS, regardless of their weight. Insulin resistance reduces the ability of cells to process glucose normally, resulting in an accumulation of glucose in the blood (hyperglycaemia). The body compensates by secreting more insulin, resulting in elevated levels of insulin (hyperinsulinaemia).

Insulin is a hormone with several different functions, particularly on the metabolism of carbohydrates, fats and proteins. Understanding these may help you understand your symptoms and treatment.

The production of insulin by the pancreas is mainly regulated by the levels of glucose in the blood. When the concentration of glucose is high, insulin secretion increases and when the level of glucose in the blood decreases, insulin production decreases as well.

Insulin exerts its function by binding to a specific receptor (a protein located in the cell membrane). In this way insulin indirectly governs the intracellular metabolic machinery to produce the desired effects without the need to enter the cell. The binding triggers many biological processes in which a key component is one of the active ingredients of Inofolic Alpha.

Insulin resistance is characterised by reduced metabolic efficiency of insulin in, for example, muscle and fat tissue; there is decreased sensitivity to insulin. Although IR is not one of the 3 diagnostic criteria, testing of blood glucose levels, fasting insulin and a protein, sex hormone binding globulin (SHBG), may help identify alterations in insulin sensitivity. Recently it was suggested that the levels of SHBG can be used as a biomarker of IR, as it has been shown that insulin reduces the synthesis of SHBG by the liver. The main role of SHBG is to mop-up excess sex hormones, including testosterone, so a lack of SHBG can lead to elevated levels of circulating testosterone.

Although the cause of PCOS is not known exactly, it is clear that hyperinsulinaemia usually plays a key role in the development of the syndrome as well as chronic inflammation and an altered gut microbiome. Find out more about how Inofolic Alpha helps with this.

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