The PCOS supplement for women for life

Insulin Resistance & PCOS

Insulin resistance (IR) impacts around 65-80% of women with PCOS, regardless of their weight. It reduces the ability of cells to process glucose normally, resulting in an accumulation of glucose in the blood (hyperglycaemia). The body compensates by secreting more insulin, resulting in elevated levels of insulin (hyperinsulinemia).

Insulin is a hormone with several different functions, particularly on the metabolism of carbohydrates, fats and proteins. Understanding these may help you understand your symptoms and treatment.

The production of insulin by the pancreas is mainly regulated by the levels of glucose in the blood. When the concentration of glucose is high, insulin secretion increases and when the level of glucose in the blood decreases, insulin production decreases as well.

Insulin works by binding to a specific receptor (a protein located in the cell membrane). In this way insulin indirectly governs the intracellular metabolic machinery to produce the desired effects without the need to enter the cell. The binding triggers many biological processes in which a key component is one of the active ingredients of Inofolic Alpha.

Insulin resistance is characterised by reduced metabolic efficiency of insulin in muscle and fat tissue. Although IR is not one of the 3 diagnostic criteria, testing of blood glucose levels, fasting insulin and a protein, sex hormone-binding globulin (SHBG) may help identify alterations in insulin sensitivity. Recently it was suggested that the levels of SHBG can be used as a biomarker of IR as it has been shown that insulin reduces the synthesis of SHBG by the liver. The main role of SHBG is to mop-up excess sex hormones, including testosterone, so a lack of SHBG can lead to elevated levels of circulating testosterone.

Although the exact cause of PCOS is not known, it is clear that hyperinsulinemia usually plays a key role in the development of the syndrome as well as chronic inflammation and an altered gut microbiome. Find out more about how Inofolic Alpha helps with this.

SHBG levels in PCOS

Sex hormone binding globulin (SHBG) is a protein that binds various hormones. If there are low levels of SHBG, there are more hormones circulating freely, which can cause the androgenic symptoms associated with PCOS. Inofolic Alpha can reduce androgen levels and the symptoms associated with it.

Metformin in Polycystic Ovary Syndrome

Metformin is used to help control insulin resistance by making the cells in the body more sensitive to insulin. Metformin is prescribed for PCOS patients to reduce insulin levels, which in turn reduce androgen levels. Unfortunately, metformin has some side effects that can be a little unpleasant. Inofolic Alpha, on the other hand, works on improving insulin sensitivity and can be used in conjunction with Metformin or sometimes instead of it. Inofolic Alpha achieves ovulation in a high percentage of those PCOS women who are not ovulating.

How to know if you have a hormonal imbalance?

Women with PCOS often have an imbalance of hormones. One way of telling if there is some imbalance in your hormones is if you experience menstrual cycle abnormalities, such as a lack of menstrual bleeding or irregular periods. If you see your GP, you will probably have a blood test which may well show some hormonal imbalance. Women with PCOS often have higher than normal androgen levels (male hormones, such as testosterone). High androgen levels can inhibit normal ovulation leading to infertility. Inofolic Alpha reduces androgen levels and achieves ovulation in 95% of those women with PCOS who do not ovulate.

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